KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0035 | - |
estrone | type 12 17beta-hydroxysteroid dehydrogenase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H + H+ | Homo sapiens | type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause | estradiol + NAD(P)+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q53GQ0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | stable expressing 17beta-HSD12 | Homo sapiens | - |
mammary gland | - |
Homo sapiens | - |
ovary | type 12 17beta-hydroxysteroid dehydrogenase is most highly expressed in ovary and mammary gland | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H + H+ | type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause | Homo sapiens | estradiol + NAD(P)+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD12 | - |
Homo sapiens |
type 12 17beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |